NON-SPECIFIC RESISTANCE INDUCED BY PALMITOYLETHANOLAMIDE was the title of a paper, published in 1972 by scientists from the Institute of Pharmacology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia.
In this paper the protective effects of PEA could be shown in different animal models. In all these models PEA could markedly reduce mortality due to infections or traumatic shock. The protective effects were more pronounced after chronic treatment. more than 12 days.
The protective effects of PEA were tested in different animal models, after injections with bacteria-toxins, Shigella dysenteriae toxin and Streptolysin O, as well as after infection with streptococci, in a big populations consisting of in total 350 mice. Furthermore the protective effects of PEA were also tested in a traumatic shock model. The dose administered was 50 mg PEA/kg BW orally.
The protective effects were impressive, and PEA could significantly reduce the mortality in all models.
PEA markedly increased the resistance of mice to Shigella dysenteriae toxin after daily oral administration of PEA. At least nine administrations were required to create the protective effects. The PEA effects became more pronounced after 12 days of administration.
In the graph above one can clearly see that the mortality is reduced my PEA much more than in the comparator arms of the study. If the toxin concentration is reduced, no mortality on PEA is seen, while some mortality still happened in the control arms of this study.
A comparable protective effect of PEA on mortality emerged after letal injections with the toxin Streptolysin O.
In the shock model the reduction of mortality due to PEA was quite clear:
The conclusion of the authors was:
Our experiments extended these observations by the finding that an amide of palmitic acid which occurs naturally in mammalian tissues given orally for 12 consecutive days, markedly increases the resistance of mice to streptococcal challenge as well as to Shigella dysenteriae toxin and Streptolysin O. Moreover, PEA pretreatment increased the tolerance to traumatic shock.
The increase of resistance was transitory and disappeared within six weeks after stopping PEA treatment.
Source: Rasková H, Masek K, Linèt O. Non-specific resistance induced by palmitoylethanolamide. Toxicon. 1972 Aug;10(5):485-90.