Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy

PEA is available in Europe as PeaPure, a supplement with the highest purity of PEA in each serving (capsule; tablet) (around 30% higher compared to een PEA-houdend product). We recommend this supplement, as it does not contain any pharmaceutical excipients, it contains PEA in a pure form.

PEA and neuro-restoration

A new scientific paper from the university of Florence, Italy, highlights the special characteristics of the natural painkiller palmitoylethanolamide (PEA). The researchers found clear indications that PEA not only inhibit pain in a natural way, but hand in hand with the painkilling properties this nutraceutical protects nerves against damage and stimulates neuro-restoration.
The authors point out that their experiments support PEA as an natural analgesic ANd a disease-modifying agent for peripheral neuropathy. This combination of special properties and a trippel action is new for a painkiller. PEA is already available in Europe as PeaPure, a nutraceutical.

PEA as a analgesic, anti-inflammatory compound and as a neuro-restorative agent

The natural compound and painkiller palmitoylethanolamide (PEA) has been explored recently by pharmacologists from the university of Florence. In their paper, bearing the tite:

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

The authors point out that neuropathic syndromes are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic with a neurorestorative effect.

N-Palmitoylethanolamine (PEA) however, exerts both an antinociceptive effect and inhibits peripheral inflammation. The authors wanted to analyse this dual mechanism of PEA in more detail. In a sciatic nerve trauma model daily treatment with PEA prevented pain threshold alterations. Repeated treatments with PEA also reduced the presence of damage in the nerves, such as edema and macrophage infiltrates. Furthermore, a significant higher myelin sheath, axonal diameter, and a number of nerve fibers were detected.

In mice without the PPAR- α target, the PEA treatment was not analgesic, neither resulted in rescue of the peripheral nerve from inflammation and other pathology.

The authors concluded that PEA has both an analgesic effect, as well can lead to neuro-restoration. Both small nerve fibres, as well as large nerve fibres can be protected by PEA:

small fibre protection

These results strongly suggest that PEA, via a PPAR- α -mediated mechanism, can directly intervene in the nervous tissue alterations responsible for pain, starting to prevent macrophage infiltration.

These findings of a combination of natural analgesia, inhibition of inflammation and nerve-protection with neuro-restorative properties is a breakthrough in the neurobiology of pain.

Di Cesare Mannelli L, D’Agostino G, Pacini A, Russo R, Zanardelli M, Ghelardini C, Calignano A. Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism. Mediators Inflamm. 2013;2013:328797. doi: 10.1155/2013/328797. Epub 2013 Feb 25.


Recently Kapoor summerized some of the protective effects of PEA in:

Emerging Neuroprotective Effects of N-Palmitoylethanolamide Besides Its Significant Antinociceptive Effects

( Kapoor S. in: Pain Med. 2013 Apr 12. doi: 10.1111/pme.12118.)

He stated:

“N-palmitoylethanolamide (PEA) exerts a number of other neuro- protective effects besides its significant antinociceptive effects.” The effects of PEA as summerized by him:

1. PEA attenuates chemotherapy-induced neuropathies by attenuating endoneueral edema in myelinated nerve fibers

2. PEA improves distal motor latency in individuals with carpal tunnel syndrome

3. PEA ehas beneficial effects in patients with multiple sclerosis by ameliorating neuropathic pain

4. PEA increases the latency between tonic clonic seizures and exhibits anti-epileptic activity

5. PEA decreases immobility in an animal model of depression, and thereby exerts a significant anti- depressant effect

6. PEA has neuroprotective effects which are a result of direct attenuation of astrocyte infiltration

7. PEA might be useful in sleep disorders such as narcolepsy as it enhances waking by modulating dopamine and anandamide levels

8. PEA might have a plausible role in Alzheimer’s disease and other forms of dementia.

9. PEA might play a plausible role in protecting neurogenic tissue from infections such as Streptococcus pneumoniae via enhancement of the phagocytic ability of microglia

He concludes:

The examples clearly illustrate the potent neuroprotective effects of PEA

3 responses

  1. Annemiek Veeke | Reply

    Geldt dit medicijn ook voor de zenuwpijn in je been dat voor een hernia operatie twee weken niet functioneel meer was? De klachten zijn nog steeds aanzienlijk na 15 jaar

    1. palmitoylethanolamide4pain | Reply

      Het is altijd handig om het in ieder geval te proberen, er zijn vooral met PeaPlex veel patienten met neuropathische pijnen goed opgeknapt. PeaPlex bevat niet alleen PEA maar ook een uitgelezen hoeveelheid zenuwondersteunende vitamines uit de B groep.

  2. Vorige week gehoord dat ik een blijvende zenuwbeschadiging aan mijn linkeronderbeen heb. Ik ben doorgestuurd naar een revalidatiearts, maar zoek daarnaast wat mij nog meer kan helpen

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