Mast cell stabilization promotes antinociceptive effects in a mouse model of postoperative pain

The mast cell appears to be more important than many scientists thought. Rita Levi-Montalcini already pointed out that mast cells are not Cinderella cells of immunology, but real diva’s!

More info on mast cells and the pathology of bladder syndrome

Mastopedia Research Feed

J Pain Res. 2013; 6: 161–166. Published online 2013 March 4. doi: 10.2147/JPR.S41527

Makoto Yasuda, Kanta Kido, Norimasa Ohtani, and Eiji Masaki



Nerve injury and consequent inflammatory responses produced by surgical incision result in a complicated pain status which still affects half of all surgical patients. Therefore, it is essential for anesthesiologists to identify the mechanisms of postoperative pain. Mast cells are resident cells of connective tissue and the mucosa that participate in the immune response. Degranulation of mast cells is involved in the development of postoperative pain and can be induced by surgical incision. The aim of this study was to investigate whether stabilization of mast cells causes an antinociceptive effect in a mouse model of postoperative pain.


Postoperative pain was induced by making an incision in the hind paw of BALB/c mice. The mast cell membrane stabilizer cromoglycate (200 μg/20 μL) was…

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