Researchers of the university of Ferrara, Italy (Dipartimento di Scienze Biomediche e Terapie Avanzate, Clinica Ginecologica e Ostetrica, Università degli Studi di Ferrara, Ferrara, Italy) analysed the efficacy of PEA in the treatment of chronic pelvic pain in women affected by endometriosis.
Twenty-four patients with endometriosis and concomitant severe pelvic pain were enrolled. All patients received two tablets a day containing 400 mg PEA; treatment period was 90 days. A Visual Analogic Scale was used for the assessment of the severity of global pain, menstrual pain, pain during intercourse and pain on voiding, among other endpoints, such as quality of life.
Via a diary the monthly consumption of painkillers was analysed. Patients were evaluated at the begin of the treatment and then monthly until the end of the study (90 days).
Statistically significant results were found in relation to pelvic pain, menstrual pain and pain during intercourse, compared to the initial evaluation of patients.
The decrease in pelvic pain lead to an improvement of the quality of life of patients and to a decreased consumption of painkillers, the nonsteroidal anti-inflammatory drugs (NSAIDs). This is of great importance, since many patients die each year due to side effects of these NSAID painkillers.
Conclusion of the authors:
PEA could be considered an effective supplement to conventional analgesic therapies in the management of pelvic pain related to endometriosis.
The fidings were published in an Italan Journal for gynaecologists (Minerva Ginecol. 2013 Mar 13.)