Mast cell activation syndromes: definition and classification

Mast cell activation syndromes are many, here a number. The mast cell can be modulated into a rest state by palmitoylethanolamide, PEA is the natural ‘break’ on mast cell activation by compounds such as NGF and TNF alpha, and other ensdogenous inflammatory inducers.

Mastopedia Research Feed

http://onlinelibrary.wiley.com/doi/10.1111/all.12126/full

http://onlinelibrary.wiley.com/store/10.1111/all.12126/asset/all12126.pdf?v=1&t=hd8m6dh5&s=6b380532e06208559c2ae78bb3baf5cdd271b0c1 

Allergy. 2013 Feb 15, Valent P, Dept of Internal Medicine I, Div of Hematology & Hemostaseology, Medical U Vienna

Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including genetic predisposition, the number and releasability of mast cells involved in the reaction, the type of allergen, presence of specific IgE, and presence of certain comorbidities. In severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above baseline. When symptoms are recurrent, are accompanied by an increase in mast cell-derived mediators in biological fluids, and are responsive to treatment with mast cell-stabilizing or mediator-targeting drugs, the diagnosis of mast cell activation syndrome (MCAS) is appropriate. Based on the underlying…

View original post 110 more words

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: