Mast cell activation syndromes are many, here a number. The mast cell can be modulated into a rest state by palmitoylethanolamide, PEA is the natural ‘break’ on mast cell activation by compounds such as NGF and TNF alpha, and other ensdogenous inflammatory inducers.
http://onlinelibrary.wiley.com/doi/10.1111/all.12126/full
Allergy. 2013 Feb 15, Valent P, Dept of Internal Medicine I, Div of Hematology & Hemostaseology, Medical U Vienna
Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including genetic predisposition, the number and releasability of mast cells involved in the reaction, the type of allergen, presence of specific IgE, and presence of certain comorbidities. In severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above baseline. When symptoms are recurrent, are accompanied by an increase in mast cell-derived mediators in biological fluids, and are responsive to treatment with mast cell-stabilizing or mediator-targeting drugs, the diagnosis of mast cell activation syndrome (MCAS) is appropriate. Based on the underlying…
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