Mast cell activation is known to occur in chronic pain syndromes of the gut. Patients suffering from these states sometimes report positive effects of the treatment with palmitoylethnanolamide. Mast cell activation also represents a cause of pelvic pain, and the same holds true.
Gastroenterology. 2013 Jan 24. pii: S0016-5085(13)00097-8. doi: 10.1053/j.gastro.2013.01.040. [Epub ahead of print]
Human Biology, Technische Universit??t M??nchen, Freising, Germany. Electronic address: firstname.lastname@example.org.
Close association between nerves and mast cells in the gut wall provides the micro-anatomical basis for functional interactions between these elements, supporting the hypothesis that a mast cell-nerve axis influences gut functions in health and disease. Advanced morphology and imaging techniques are now available to assess structural and functional relationships of the mast cell-nerve axis in human gut tissues. Morphological techniques including co-labeling of mast cells and nerves serve to evaluate changes in their densities and anatomical proximity. Calcium (Ca(++)) and potentiometric dye imaging provide novel insights into functions such as mast cell-nerve signaling in the human gut tissues. Such imaging promises to reveal new ionic or molecular targets to normalize nerve sensitization induced by mast cell hyperactivity or…
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