Montalcini explains the protective role of the ALIA-mides

Professor Rita Levi-Montalcini introduced the term ALIA-mides in her paper: A proposed autacoid mechanism controlling mastocyte behaviour. ( Agents Actions 1993;39 Spec No:C145-7).
In this paper she introduced this word ALIA as Autocoid Local Inflammatory Antagonism, and discovered one of the key mechanisms of action of one of such an ALIA-mide, palmitoylethanolamide. Autocoid is a biological term for a tissue hormone, a regulating substance, locally produced and locally active. Prostaglandines are such autocoids. The ALIA-mides are autocoids with a specific protective rol during inflammation. Palmitoylethanolamide regulates mast cells to rest and counteracts Nerve Growth Factor, which is the positive feedbackloop, influencing mast cells to become hyperactive.

Professoressa explains:


Schermafbeelding 2013-02-02 om 20.03.57

Schermafbeelding 2013-02-02 om 20.03.52

Schermafbeelding 2013-02-02 om 20.03.59

Schermafbeelding 2013-02-02 om 20.03.56

Schermafbeelding 2013-02-03 om 11.27.03

And I conclude with a footnote to explain my scedule of the action of PEA as an ALIA-mide on inflammatory cells and on nerve cells. Clearly PEA and other ALIA-mides bring rest to overactive nerve cells (activated via excitatory neurotransmitters) and overactive inflammatory cells (activated by NGF and related molecules such as TNF-alpha).

Schermafbeelding 2013-02-03 om 11.27.06

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: