Paper discussed by Montalcinni:
CNS Neurol Disord Drug Targets. 2011 Dec;10(8):916-20.
Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy.
Truini A, Biasiotta A, Di Stefano G, La Cesa S, Leone C, Cartoni C, Federico V, Petrucci MT, Cruccu G.
All together, the results reported here indicate that PEA may represent an innovative therapeutic tool for patients undergoing chemotherapy-induced painful neuropathy to obtain pain relief as well as to restore myelinated-fibre function without increasing the toxic effects that they were already enduring. Although a proper randomised controlled study (possibly using a drug with established efficacy in relieving pain as a control) is necessary to confirm the efficacy of PEA therapy, the present study provides evidence concerning the ability of an endogenous fatty acid amide to improve neurophysiologic parameters in humans.