Palmitoylethanolamide protects nerves in chemotherapy: Montalcini explains

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PEA and Kahler: palmitoylethanolamide protects

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Neurophysiological parameters after PEA in chemotherapy

Palmitoylethanolamide ( PeaPure) against chemotherapy

Copyright.svgCopyright on all cartoons by the Chronic Pain Coalition, JMKHLOGO

Paper discussed by Montalcinni:

CNS Neurol Disord Drug Targets. 2011 Dec;10(8):916-20.
Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy.
Truini A, Biasiotta A, Di Stefano G, La Cesa S, Leone C, Cartoni C, Federico V, Petrucci MT, Cruccu G.

Conclusion authors:

All together, the results reported here indicate that PEA may represent an innovative therapeutic tool for patients undergoing chemotherapy-induced painful neuropathy to obtain pain relief as well as to restore myelinated-fibre function without increasing the toxic effects that they were already enduring. Although a proper randomised controlled study (possibly using a drug with established efficacy in relieving pain as a control) is necessary to confirm the efficacy of PEA therapy, the present study provides evidence concerning the ability of an endogenous fatty acid amide to improve neurophysiologic parameters in humans.

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