Palmitoylethanolamide (PEA): clinical trial overview for MD’s

PEA is very much evidence based, although many physicians have missed this, due to the fact that:

1. PEA is classified as a supplement under the name PeaPure or dietfood for medical purposes under the name een PEA-houdend product

2. Some of the clinical trials have been published in Italian medical journals.

In the following list you find all clinical trials collected on the efficacy and safety of een PEA-houdend product. Thirthynine clinical trials have been conducted so far, some have been reported in English medical journals, but due to the language barrier many results have been published in Italian or Spanisch Journals for neurologists or anesthesiologists and painspecialists only. The first 5 clinical trials are already more than half a century old and were conducted in the Czech republic, were palmitoylethanolamide was tested as an anti-inflammatory agent. The trials done in this century mostly focus on palmitoyethanolamide as an analgesic/anti-inflammatory agent.

For the review of colleagues we herewith disclose the key findings of all these trials in this document.

Total number of studies

In total there are nearly 300 studies published were palmitoylethanolamide has been referred to. In the table below the number of publications related to PEA for each year. We see the first publications more than half a century ago, with a dip between 1984 and 1994. Around that time professor Levi-Montalcini, Nobelprice laureate focussed on PEA and this was the beginning of a surge of publications. We will here review the clinical publications only.

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