Pain due to a bladder which feels itself not totally well. There is no infection, that is clear, no bacteria in the urine. But the bladder aches. Why? We call chronic pain on the bladder area, pain during voiding and sometimes even burning pain, the painful bladder syndrome. Syndrome, because we do not understand the reason for the pain.
Inflammation in the bladder wall: mast cells
But if we take a biopsy of the bladde wall we see chronic inflammatory cells and especially the so called mast cells. These cells are there at war, but sadly enough there is no enemy. Normally the enemy would be a bacteria. Why this low grade inflammation has been triggered we do not know. But the same ‘shit’ happens in chronic prostate pain.
This war without an enemy, leading to the chronic pain syndrome in the bladder, can be treated with a natural and bodyown anti-inflammatory compound, which also has painkilling properties. This molecule has the fancy name palmitoylethanolamide, or easier PeaPure, a supplement.
In the period 1993-1996 the Nobel prize laureate professor Rita Levi-Montalcini focussed on this substance to easy chronic pain and normalize the war-behavior of these mast cells. (She was at that time 87 years old, and she is evn now still bright and alive….) Furthermore, palmitoylethanolamide (PEA) brings to rest overactive nerve cells which are irritated in all chronic painsyndromes.
PEA has been used now by more than 800.000 patients, most of them in Europe, and the compound is easy to use, has no troublesome side effects and can be used safely together with other drugs. Also for older patients there are no issues of drowsiness to be expected.
Start with a daily dose of 1200 mg/day, increase after 1 month to double dose. If there is less pain after, say 5 weeks, you can lower the dose to 1200 mg/day again. If pain increases, increase the dose.