Chronic prostate pain and PEA (PeaPure, PeaPlex)

Pain due to a prostate which feels itself not totally well. There is no infection, that is clear, no bacteria in the urine. But the prostate aches. Why? We call chronic pain on the prostate area pain during voiding and sometimes even burning pain, chronic painful prostatism.

In the prostate there is something strange happening. Inflammation cells are there at war, but sadly enough there is no enemy. Normally the enemy would be a bacteria. Why this low grade inflammation has been triggered we do not know. But it happens in chronic prostate pain. One of the main war-cells is the mast cell.

This war without an enemy, leading to the chronic painsyndrome in the prostate can be treated with a natural and bodyown anti-inflammatory compound, which also has painkilling properties. This molecule has the fancy name palmitoylethanolamide, or easier PeaPure or PeaPlex. In 1995 the Nobelprize leaureate professor Rita Levi-Montalcini focussed on this substance to easy chronic pain and normalize the war-behavior of these mast cells. (She was at that time 87 years old, and she died at the age of 2003…) Furthermore, palmitoylethanolamide brings to rest overactive nerve cells which are irritated in all chronic painsyndromes.

PEA has been used now by more than 800.000 patients, most of them in Europe, and the compound is easy to use, has no troublesome side effects and can be used safely together with other drugs. Als for older patients there are no issues of drowsiness to be expected.

The dose is three times daily 400 m capsules.  If there is less pain after, say 5 weeks, you can lower the dose to 400 mg twice daily. If pain increases, increase the dose up to 3 times daily 2 capsules.


Papadoukakis S, Kyroudi-Voulgari A, Truss MC, Perea D, Mitropoulos D. | Quantitative study of mast cells in experimentally induced benign prostatic hyperplasia. | Urol Int. | 2010;84(1):100-4. Epub 2010 Feb 17.

Mehik A, Leskinen MJ, Hellström P. | Mechanisms of pain in chronic pelvic pain syndrome: influence of prostatic inflammation. | World J Urol. | 2003 Jun;21(2):90-4. Epub 2003 Apr 17.

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