Self healing ability supported by ‘Autacoid Medicine’: the case of PEA

Chairman of the Dutch IOCOB foundation discussed the fundamentals of the self healing ability of our body in his article about autacoid medicine in the medical journal Anaesthesia, Critical Care and Pain Management. Earlier this year he already described several principles elsewhere. [1]

The article also mentions a few examples of people that were treated with the natural substance palmitoylethanolamide (PEA). One patient responded better to PEA capsules with vitamin B (PeaPlex) than pure PEA capsules, an interesting example of the synergy between substances in the body.

The start of autacoid medicine

In 1986 a speech was given in Washington by a well-known professor that was doing a lot of research on the receptors in the brain. Specifically those receptors responsible for the creation of fear and pain. The PEA innovators of the company Epitech translated this lecture in Italian, it is sadly enough not available in English.

Professor Erminio Costa indicated during his speech that when looking for new cures it is very important to follow the path of healing that nature has created in our bodies in her millions of years of development. He explained that our body contains many healing mechanisms that can be activated by giving them specific substances. It goes without saying that when you activate one of these self-healing mechanisms, it creates a lot less side effects than when taking a pharmaceutical substance. After all, classical pharmaceutical substances are foreign to the body.

Molecules that are foreign to the body have to be broken down. The body possesses an extensive mechanism to break down natural molecules, but pharmaceutical molecules are foreign to the body and are not always recognized by the enzymes in our body that break down substances.

The message of Professor Costa didn’t get heard around the world, only partly in Italy, where the companies LifeGroup and the successor company Epitech worked on PEA. This is due to the fact that the speech was only translated in to Italian, as said, and not into English. However, the principle that Professor Costa discussed here can turn in to a new leading principle in medicine.

In the last few years there have been a number of professors that developed the principle that professor Costa explained during his speech. You could call this principle ‘starting a physiological incline’ or activating and supporting the self-healing ability of the body.

This type of medicine is known in a small circle as ‘autacoid medicine’, partly due to the articles by Keppel Hesselink. An autacoid is a self-healing molecule, ‘auto’ stands for self and ‘coid’ stands for healing.

A number of molecules have become known since the 90’s that increase and support self-healing abilities in our body. Knowledge around these molecules is part of autacoid medicine.

It’s about time that more knowledge from autacoid medicine starts being used!


[1] Keppel Hesselink JM1. | The terms ‘autacoid’, ‘hormone’ and ‘chalone’ and how they have shifted with time. | Auton Autacoid Pharmacol. | 2015 Dec;35(4):51-8. doi: 10.1111/aap.12037. Epub 2016 Mar 29.


Eczema in children: what can be done about it, about palmitoylethanolamide crem

Eczema is common among children and brings parents to desperation about their child scratching. What can be done?

Eczema in children is becoming more and more common. It seems to have increased a lot over the last few years. Children suffer from the condition a great deal and can’t control their tendency to scratch. The pain and itching caused by eczema can bring the child out of balance considerably and also drives the parents to the edge. The entire family suffers from the crying and interrupted sleep patterns. We often call this atopic eczema or constitutional eczema. Whatever you call it, the skin is red, flaky, itchy and full of scratches. (Eczema is the medical term for skin that is red, flay and itches.)

Too little anti-inflammatory fatty acids in the skin

Meanwhile we know that in case of a chronically inflamed skin that itches, the natural fatty acids in the skin that are anti-inflammatory are insufficiently present. One of the most important fatty acids of this group is palmitoylethanolamide. Since a new cream became available that contains a high concentration of this natural fatty acid, a new treatment can be provided. More about this later.

How to treat eczema in children

Science hasn’t found a good answer on how to treat eczema in children. Most anti-eczema medication contains nasty ingredients with many side effects, which you don’t want to give to your child, especially hormone creams or creams that contain tar (pix liquida, yuk!). Moreover, very little research has actually been conducted on the best treatment for children. In a treatment journal (The Dutch GeBu) frequently consulted by doctors it literally says:

When this article was written it turned out that the available double blind and randomized studies on treatment of eczema in children was limited in size and of average quality. Contrary to what is customary in this medical journal, part of the advice given in this article is not based on scientific evidence, but on practical opinions and experiences.

Eczema in children, constitutional eczema

Eczema in children in is a chronic condition that occurs in 5% of all infants and toddlers. This skin condition also goes by the name of atopic eczema or constitutional eczema. It’s important to know that this condition is not contagious and parents don’t have to worry that the condition is due to bad skin care. It is genetically determined if a child has eczema or not, presumably by allergic stimuli. The genetic constitution also plays a role in the development of asthma, asthmatic bronchitis and hay fever, which is often seen in combination with atopic eczema in children. Stimuli like temperature and humidity changes, house dust mite and pets can flare up eczema in sensitive children.

Eczema in children: itching, redness, flaking and scratching

Eczema in children starts to occur between 1 to 4 months after birth. Red, itching, sometimes damp skin rash, often with small blisters, starts to become visible on the face and between the hair on the head, but also on arms and legs. The itching especially is bothersome. The infant or toddler will try to subdue the itching by scratching, which unfortunately will only aggravate the eczema. It’s easy to understand these kids can be restless and cry often, also at night.

Eczema in children comes in ebbs and flows, some periods are fine and suddenly it may flare up again. Over half of the children will stop having complaints after their third year. However, some children remain that keep having symptoms and are chronically treated with creams that contain corticosteroids, which is no good as these are hormones.

A study conducted on over 300 children between the ages of 6 months and 15 years old, showed treatment with PEA cream improved all of their symptoms. Less redness, less skin flaking, less itching and discomfort. On the picture above we can see one of these children, with eczema around the belly button, before and after the treatment with PEA cream.

PEA cream was invented a long time ago, in 1994, patented by an Italian group. This group never developed the cream, so it seems. Other patents for PEA creams have been written after that, including one interesting one where it was found that when treated with PEA cream there was less need for corticosteroids.

Natural treatment of eczema in children

Science has nothing to offer these children that has proven effective and safe. This is clearly stated in the medicine journals. No parent is eager to give their child cream that contains hormones.

This is why it’s good that there’s a cream with an natural anti-inflammatory, anti-itching and pain reducing substance in it: palmitoylethanolamide (PEA). This PEA cream is available without prescription and has shown great results. PEA cream has been available since 2004. It has been evaluated in several studies and showed to reduce pain, redness and damage to the skin, as well as decrease itching. The first PEA cream, however, only contained a low dose of PEA (less than 0,5%). There is a cream available nowadays with a higher dose of PEA (1,5%) combined with the natural anti-inflammatory Boswellia.

The logic behind treating eczema in children with PEA seems clear:

  1. The skin contains the natural anti-inflammatory substance PEA.
  2. Chronic skin conditions like dermatitis and eczema decrease the synthesis of this substance.
  3. By supplementing PEA by using a cream the skin is brought back in to balance.

There are no side effects to using PEA cream. The cream base is neutral, it protects the skin against dryness and also has no know side effects. It is still recommended to test a small amount of cream, just in case of an unexpected allergic reaction to the base cream. This is very rare, but better to test it before applying a large amount of cream to other parts of the body. PEA cream has been extensively and scientifically tested:

  1. On approximately 2000 patients with atopic eczema and hundreds of children with eczema.
  2. On patients with skin damage due to radiation for cancer treatment.
  3. On patients with severe itching and skin problems due to kidney dialyses.

The fact that the outcome was of high clinical importance is evident by this quote from one of the studies on the protection of radioactive radiation on the skin: “Results from the Trento study show that 4 out of 5 patients receiving radiotherapy for head and neck cancer and using palmitoylethanolamide cream experience only a mild or no skin reaction”

Nobody knows how to prevent eczema in children. The GeBu says:

The effectiveness of preventative measure is unknown. Practically it is advised to change diapers frequently and possibly use paper diapers.

Other practical tips include: Don’t use woolen clothing for your children, it itches and can aggravate the eczema. Cotton clothing is preferred. Synthetic clothing should be avoided too.

Sources: about the diverse effects of PEA cream on skin

PEA containing cream in atopic dermatitis: results of a comparator trial; repairing the skin


PEA containing cream in atopic dermatitis: results of a comparator trial; repairing the skin

PEA creme: palmitoylethanolamide in beschermende creme, tegen pijn en jeuk

Kircik L. A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis. J Drugs Dermatol. 2010 Apr;9(4):334-8.

Phan NQ, Siepmann D, Gralow I, Ständer S. Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia. J Dtsch Dermatol Ges. 2010 Feb;8(2):88-91. doi: 10.1111/j.1610-0387.2009.07213.x. Epub 2009 Sep 10. English, German.

Eberlein B, Eicke C, Reinhardt HW, Ring J. Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). J Eur Acad Dermatol Venereol. 2008 Jan;22(1):73-82. doi: 10.1111/j.1468-3083.2007.02351.x.

Kemeny L, Koreck A, Kis K, Kenderessy-Szabo A, Bodai L, Cimpean A, Paunescu V, Raica M, Ghyczy M. Endogenous phospholipid metabolite containing topical product inhibits ultraviolet light-induced inflammation and DNA damage in human skin. Skin Pharmacol Physiol. 2007;20(3):155-61. Epub 2007 Jan 17.

Ständer S, Reinhardt HW, Luger TA. [Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus]. Hautarzt. 2006 Sep;57(9):801-7. German.

Szepietowski JC, Szepietowski T, Reich A. Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study. Acta Dermatovenerol Croat. 2005;13(2):97-103.

Garcia BD, Goldman MP, Gold MH. Comparison of pre- and/or postphotodynamic therapy and intense pulsed light treatment protocols for the reduction of postprocedure-associated symptoms and enhancement of therapeutic efficacy. J Drugs Dermatol. 2007 Sep;6(9):924-8.

Abramo F, Campora L, Albanese F, della Valle MF, Cristino L, Petrosino S, Di Marzo V, Miragliotta V. Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. BMC Vet Res. 2014 Jan 14;10:21. doi: 10.1186/1746-6148-10-21.

Abramovits W, Perlmutter A. Steroids versus other immune modulators in the management of allergic dermatoses. Curr Opin Allergy Clin Immunol. 2006 Oct;6(5):345-54. Review.

Lambert DM, Vandevoorde S, Jonsson KO, Fowler CJ: The palmitoylethanolamide fam- ily: a new class of anti-inflammatory agents? Curr Med Chem 2002;9:663–674.

Anti-flu medicine: clinical studies prove effectiveness of a new natural treatment


In August 2013, two Dutch professors revealed a new treatment in an international medical journal to prevent and treat flu and colds using a natural substance. The substance concerned in called PEA, short for Palmitoylethanolamide.

Forgotten studies brought back to attention

These professors discovered that six large studies were conducted in the 70’s on over more than 3000 people. These studies were forgotten over time. However, these were well conducted studies, double blinded and placebo controlled, with standards that are still valid today. The substance subject to the research was PEA and it’s effectiveness on fly and colds.

Anti-flu medicine: some exist, but are quite controversial

The treatment and prevention of flu has caused a lot of waves recently. It became clear that pharmaceutical anti-flu drugs like Tamiflu and Relenza cause many nasty side effects and may not even be effective at all. The flu vaccine has been a hot topic as well. Even among top experts we see the opinions differ. Recent extensive studies of the effectiveness of the vaccines on flu are less optimistic than earlier studies.

In all six studies that were mentioned in the article, PEA proved to be very safe (no side effects were reported) and the chance of flu clearly and significantly decreased. On top of that it could also reduce the severity of the symptoms, once contracted. This also proved true for children, even as young as 4 years old.


JM. Keppel Hesselink, Tineke de Boer, Renger F. Witkamp. Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold. International Journal of Inflammation Volume 2013 (2013), Article ID 151028, 8 pages

PEA en psoriasis

Reblogged: PEA en psoriasis

Door de ontstekingsremmende werking kan palmitoylethanolamide ingezet worden bij psoriasis. Palmitoylethanolamide heeft naast een ontstekingsremmende, ook een celbeschermende en pijnstillende werking.

PEA speelt als lichaamseigen stof een belangrijke rol in de pathogenese van  immuungemedieerde ziekten waaronder auto-immuunziekten en chronische ontstekingsprocessen. Het brengt de balans terug binnen het verstoorde immuunsysteem door in de cel de inflammatoire cascade te deactiveren.

Een gemene deler in verschillende inflammatoire aandoeningen is overactiviteit van TNF-α. Dit is onder meer het geval bij onder andere psoriasis dat zich kenmerkt door een (periodiek) actief ontstekingsbeeld. Zowel door het remmen van de activiteit van niet-neuronale cellen, als door de antagonistische werking op het overactieve TNF-α, wordt de ontstekingsactiviteit geremd.

Behandeling met PEA kan mogelijk het ziekteverloop bij psoriasis dan ook gunstig beïnvloeden. Dit geldt eveneens voor andere aandoeningen waarbij de regulatie van inflammatoire processen geassocieerd wordt met de PPAR-α-receptor.

Behalve een goede effectiviteit is daarnaast de verdraagzaamheid van exogeen PEA veel groter ten opzichte van reguliere ontstekingsremmers die protocollair worden ingezet. (31,32)

31. J Clinical and aestetical dermatology, june 2014
32. Eczeem natuurlijk behandelen met PEA creme en PEA supplement. IOCOB. Beschikbaar via:

Neuropathische pijn behandelen met pregabaline en palmitoylethanolamide

Patienten met neuropathische pijn klagen vaak over bijwerkingen van te hoge doseringen Lyrica. Lyrica is de handelsnaam van pregabaline.

Een neuroloog heeft 30 patienten behandeld met Lyrica, samen met palmitoylethanolamide. Deze combinatie was effectief, zonder bijwerkingen:


30 patients ranging between 32 to 78 years, suffering from neuropathic pain, were treated with pregabalin and palmitoylethanolamide for 45 days. All patients have completed the study and no side effect was reported; in all patients it has been observed a significant reduction of pain intensity that was associated to a better quality of the sleep. The improvement of the clinical symptomatology was associated to a recovery of quality of sleep and to a good subjective evaluation of the effectiveness of the therapy. In conclusion, the efficacy of a new multitherapeutic approach for neuropathic pain, based on pregabalin + palmitoylethanolamide has been proved; the therapy showed to be safe and allows patients to have a better quality of life.

Bron: Combination of pregabalin and palmitoylethanolamide (PEA) for neuropathic pain treatment

Kanker pijn door gemetastaseeerd prostaat carcinoom meer dan 50% minder met PeaPlex

Een 59-jarige man, Hoogleraar aan een Nederlandse universiteit, had sinds jaren gemetastaseerd prostaat carcinoom. Hij was behandeld met chemotherapie daarvoor. Na de chemotherapie begon hij last t…

Source: Kanker pijn door gemetastaseeerd prostaat carcinoom meer dan 50% minder met PeaPlex

Cancerpain due to metastasis of prostate carcinoma 50% less by PeaPlex

A 59 year old man, suffering from metastatic prostate carcinoma, was treated for the pain by amitriptyline. He was also suffering from neuropathic pain, due to the chemotherapy he was prescribed. The amitriptyline was inducing drowsiness, and as the patient was a professor at an university he was not particularly fond of this TCA.

We started treating with palmitoylethanolamide and vitamin B complex, combined in PeaPlex. Within a month the pain decreased, both in his feet as well as in the shoulders and arms, due to the metastases.

After 2 month the pain was decreased for more than 50%, and his general condition was very much improved.

Vraag: hoe lang moet ik met PEA doorgaan bij artrose van de handen en polsen

Vraag: Ik ben een vrouw van 59 jaar die al gedurende 10 jaar in toenemende mate last heeft van pijn aan polsen, duim gewricht en vingers. Het begon toen ik net 50 geworden was, na een natte herfst.…

Source: Vraag: hoe lang moet ik met PEA doorgaan bij artrose van de handen en polsen

Over de veiligheid van palmitoylethanolamide (PEA) en waarom dat belangrijk is.

De vraag naar hoe veilig een capsule is die gevuld is met palmitoylethanolamide is een belangrijke vraag. Kan ik zonder problemen deze capsule gedurende een jaar innemen? Zijn er bijwerkingen van d…

Source: Over de veiligheid van palmitoylethanolamide (PEA) en waarom dat belangrijk is.

Over de veiligheid van palmitoylethanolamide (PEA) en waarom dat belangrijk is.

De vraag naar hoe veilig een capsule is die gevuld is met palmitoylethanolamide is een belangrijke vraag. Kan ik zonder problemen deze capsule gedurende een jaar innemen? Zijn er bijwerkingen van deze capsule te verwachten?

Waarom zijn die vragen belangrijk?

Omdat je vaak PEA langdurig inneemt, soms weken tot maanden en zelfs jaren. En omdat je dan zeker wilt weten dat op de lange termijn er geen problemen optreden.

Sinds ongeveer zes jaar zijn er in Nederland capsules te verkrijgen die gevuld zijn met palmitoylethanolamide. Meteen na de introductie ervan hebben een aantal artsen vele patiënten langdurig met deze capsules behandeld. De capsules waren gevuld met zuivere palmitoylethanolamide. Maar dat kan je nu wel zeggen belangrijker is of je het ook kan aantonen. Pas als een groot aantal patiënten langere tijd dit middel gebruikt heeft, en een arts heeft er op toegezien, dan weet je dat inmiddels veilig is.

Nieuwe ongeteste capsules PEA

Er zijn inmiddels vele producenten in de wereld die beweren zuiveren PEA in capsules te hebben. Wij hebben een aantal capsules gecontroleerd, en zijn tot de conclusie gekomen dat niet in elke capsule zit wat er op staat. Belangrijker nog is of uitgesloten is dat bij de productie chemische oplosmiddelen gebruikt zijn. Vooral bij producent zit met weinig ervaring die snel snel snel wat kilo’s willen maken weten niet van oplosmiddelen die aanwezig zijn in het eindproduct, als je het op een goedkoopje aanschaft. Ook weten experts inmiddels dat capsules afkomstig zijn van onduidelijke bronnen in omloop zijn, die gevuld zijn met talk of met een ander fijn verdeeld wit materiaal. Als capsules heel goedkoop zijn of er wordt gestunt met bijzondere aanschaf voorwaarden, dan gaat het meestal om capsules die net op de markt zijn, die net geproduceerd zijn, en die dus niet uitgebreid en langdurig getest zijn.

Omdat de veiligheid voor alles gaat, adviseren experts daarom om de keuze te beperken tot capsules die gevuld zijn met PEA en waarvan bekend is dat ze langdurig op veiligheid getest zijn, en dat zijn capsules die voorzien zijn van het keurmerk PEA-opt. Ook als je capsules kan krijgen waar ben je na enkele dagen tot weken denkt ze werken echt, weet je nog niet of die zelfde capsules ook veilig zijn als je langdurig inneemt. Werkzaamheid is dus geen garantie voor veiligheid. Vandaar dat wij altijd adviseren om de veiligheid voor te laten gaan.

Daarom schrijft het Instituut voor Neuropathische Pijn:

Aanwijzing: Kies steeds voor PEA capsules met het PEA-opt keurmerk, die hebben niet alleen een gegarandeerde hoge zuiverheid, en zijn gemaakt op basis van een gepatenteerd productieproces. Alleen hiervan is de klinische werkzaamheid en veiligheidbewezen. En door ons beschreven in medische tijdschriften! Van andere PEA capsules is vaak de zuiverheid niet eens na te trekken. Wij en andere behandelaars hebben slechte ervaringen met lage-kwaliteits-capsules. Sommigen blijken zelfs totaal ongeschikt te zijn voor humane consumptie.


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